SORAFENAT 200 mg Tablet
Uses of SORAFENAT 200 mg Tablet
SORAFENAT; to treat renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and thyroid cancer.
How it Work
Sorafenib is a potent kinase inhibitor and selective multi-targeted receptor tyrosine kinase inhibitor that blocks tumour growth and inhibits angiogenesis.
Common Side Effects
Common side effects include; Acne-like rash is reported very commonly. Other common adverse effects include: diarrhoea, nausea, vomiting, anorexia, hair loss.
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*Follow your doctor’s advice.
*Always take medicine after food.
*Take the medicine with water.
Fast Fact
As Sorafenib is a selective chemotherapeutic agent, its tolerability profile is better than previous cytotoxic agents. Adverse drug reactions (ADRs) are acceptable for a potentially fatal disease.
Frequently Asked Question
Sorafenib blocks some of the protein kinases and is called a multi-kinase inhibitor. It works in two ways. It stops signals that tell cancer cells to grow. It also stops cancer cells forming new blood vessels, which they need to grow.
- Skin and eyes that appear yellowish (jaundice).
- Abdominal pain and swelling.
- Swelling in the legs and ankles.
- Itchy skin, Dark urine color.
The drug sorafenib, which is already used for some liver cancers that can’t be removed surgically, works in part by hindering new blood vessel growth. This drug is now being studied for use earlier in the course of the disease, such as after surgery or trans-arterial chemoembolization (TACE).
Common combination chemotherapy regimens
| Cancer type | Drugs |
|---|---|
| Breast cancer | Cyclophosphamide, methotrexate, 5-fluorouracil, Doxorubicin, Gefitinib |
| Hodgkin’s disease | Docetaxel, doxorubicin, cyclophosphamide, Doxorubicin, bleomycin, vinblastine, dacarbazine |
| Non-Hodgkin’s lymphoma | Cyclophosphamide, doxorubicin, vincristine, prednisolone |
| Germ cell tumor | Bleomycin, etoposide, cisplatin, |
| Stomach cancer | Epirubicin, cisplatin, capecitabine, 5-fluorouracil |
| Bladder cancer | Methotrexate, vincristine, doxorubicin, cisplatin |
| Lung cancer | Cyclophosphamide, doxorubicin, vincristine, Gefitinib, Erlotinib |
| Colorectal cancer | 5-fluorouracil, folinic acid, oxaliplatin |
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