As monotherapy.  When diet and exercise alone adequate and for whom metformin is inappropriate.

As dual oral therapy in combination with metformin. In patients with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin, sulphonylurea, and thiazolidinedione.

As triple oral therapy in combination with sulphonylurea and metformin. When diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control.

Vidagliptin in combination with insulin with or without metformin. when diet and exercise plus a stable dose of insulin do not provide adequate control.