ERLOTAB 150 mg Tablet
ERLOTAB; to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer.
Erlotinib is an EGFR inhibitor, like gefitinib, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Therefore, it is only effective in cancers with mutated and overactive EGFR.Gefitinib is the first selective inhibitor of epidermal growth factor receptor’s (EGFR) tyrosine kinase domain. Thus gefitinib is an EGFR inhibitor. The target protein (EGFR) is a member of a family of receptors (ErbB). Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the anti-apoptotic Ras signal transduction cascade is inhibited, and malignant cells are inhibited.
Common side effects include; Acne-like rash is reported very commonly. Other common adverse effects include: diarrhoea, nausea, vomiting, anorexia, hair loss.
Moreover,
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*Follow your doctor’s advice.
*Always take medicine after food.
*Take the medicine with water.
Fast Fact
As Erlotinib is a selective chemotherapeutic agent, its tolerability profile is better than previous cytotoxic agents. Adverse drug reactions (ADRs) are acceptable for a potentially fatal disease.
The EGFR gene provides instructions for making a receptor protein “the epidermal growth factor receptor”, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. … Ligands and receptors fit together like keys into locks.
EGFR mutation testing is used primarily to help guide treatment and determine whether someone with non-small cell lung cancer (NSCLC) may benefit from targeted therapy such as with the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib.
Common combination chemotherapy regimens
| Cancer type | Drugs |
|---|---|
| Breast cancer | Cyclophosphamide, methotrexate, 5-fluorouracil, Doxorubicin, Gefitinib |
| Hodgkin’s disease | Docetaxel, doxorubicin, cyclophosphamide, Doxorubicin, bleomycin, vinblastine, dacarbazine |
| Non-Hodgkin’s lymphoma | Cyclophosphamide, doxorubicin, vincristine, prednisolone |
| Germ cell tumor | Bleomycin, etoposide, cisplatin, |
| Stomach cancer | Epirubicin, cisplatin, capecitabine, 5-fluorouracil |
| Bladder cancer | Methotrexate, vincristine, doxorubicin, cisplatin |
| Lung cancer | Cyclophosphamide, doxorubicin, vincristine, Gefitinib, Erlotinib |
| Colorectal cancer | 5-fluorouracil, folinic acid, oxaliplatin |
Vitamins
Cough syrups
Miglitol and Acarbose
Metoprolol and Hydrochlorothiazide
Metoprolol and Hydrochlorothiazide
Cold and Flu
Metoprolol and Hydrochlorothiazide
Medicines
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