GTN SORBITRATE CR 6.4 mg Tablet

Uses of  GTN SORBITRATE CR 6.4 mg Tablet

GTN SORBITRATE CR 6.4 mg Tablet, is a medication most commonly used for heart diseases. This specifically includes Angina pectoris, Chronic heart failure.

How it Work

Nitroglycerin belongs to a group of drugs called nitrates. Which includes many other nitrates like Isosorbide dinitrate, Isosorbide mononitrate. for angina pectoris, a painful symptom of ischemic heart disease caused by inadequate flow of blood and oxygen to the heart and as a potent antihypertensive agent. Nitroglycerin corrects the imbalance between the flow of oxygen and blood to the heart.

At low doses, nitroglycerin will dilate veins more than arteries, thereby reducing preload (volume of blood in the heart after filling); this is thought to be its primary mechanism of action. By decreasing preload, the heart has less blood to pump which decreases oxygen requirement since the heart doesn’t have to work as hard. Additionally, having a smaller preload reduces the ventricular transmural pressure (pressure exerted on the walls of the heart), which decreases the compression of heart arteries to allow more blood to flow through the heart.

At higher doses, it also dilates arteries, thereby reducing afterload (decreasing the pressure against which the heart must pump). Improved myocardial oxygen demand vs oxygen delivery ratio leads to the following therapeutic effects during episodes of angina pectoris. Such as subsiding of chest pain, decrease of blood pressure, increase of heart rate, and orthostatic hypotension.

Common Side Effects

Common side effects include headache, feeling tired, orthostatic hypotension (sudden lowering of blood pressure on standing).

Moreover,

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It is shown that continuous exposure to nitrates can cause the body to stop responding normally to this medicine.

Nitroglycerin (NG), also known as nitroglycerine, trinitroglycerin (TNG), glyceryl trinitrate (GTN), or 1,2,3-trinitroxypropane.

*Follow your doctor’s advice.